Importance of platelet-derived growth factors in liver regeneration
نویسندگان
چکیده
منابع مشابه
Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration
Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regula...
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Liver recapitulates the same size as before partial hepatectomy (PH). Once hepatectomized, tumor necrosis factor (TNF) a and interleukin (IL)-6 are secreted from non-parenchymal cells. The cytokines promotes hepatocyte proliferation via signal transducer and activator of transcription 3. Hepatocyte growth factor and epidermal growth factor are potent mitogen of hepatocytes. CCAAT/enhancer bindi...
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Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-alpha signaling in gastrulation and in the development of the cranial and cardiac neural crest, gonads, lung, intestine, skin, CNS, and skelet...
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Renal fibrosis is the hallmark of chronic kidney disease progression and is characterized by an exaggerated wound-healing process with the production of renal scar tissue. It comprises both the glomerular and the tubulointerstitial compartments. Among the factors that contribute to kidney fibrosis, the members of the platelet-derived growth factor (PDGF) family are among the best characterized ...
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The capability of the liver to fully regenerate after injury is a unique phenomenon essential for the maintenance of its important functions in the control of metabolism and xenobiotic detoxification. The regeneration process is histologically well described, but the genes that orchestrate liver regeneration have been only partially characterized. Of particular interest are cytokines and growth...
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ژورنال
عنوان ژورنال: Expert Review of Gastroenterology & Hepatology
سال: 2016
ISSN: 1747-4124,1747-4132
DOI: 10.1586/17474124.2016.1158100